Author	Control group	Design	ITT sample size			PP sample size
Author	Control group	Design	RC	Control	Total	RC	Control	Total
Baumer P [35]	Placebo	DB	96	102	198	96	102	198
Hamza H [36]	Placebo	DB	32	39	71	32	38	71
Vetel JM (multidose)^*	Placebo	DB	173	54	112	173	54	112
Moraes E [36]	Sb	SB	207	197	404	175	161	404
Coffin B & Rampal P^*	Placebo	DB	86	87	173	83	87	173
Rogé J [38]	Loperamide	DB	40	36	76	37	32	76
Vetel JM [39]	Loperamide	DB	82	75	157	77	70	157
Prado D [40]	Loperamide	SB	473	472	945	473	471	945
Coulden S^*	Loperamide	SB	60	60	120	60	60	120
Lin Sanren SB006^*	Loperamide	SB	112	111	223	111	104	223
Wang HH [41]	Loperamide	SB	31	31	62	31	31	62
Gallelli L [42]	Loperamide	DB	30	31	61	30	31	61
All studies versus placebo (n = 5)			594	479	1073	559	442	1001
All studies versus loperamide (n = 7)			828	816	1 644	819	799	1618
All studies (n = 12)			1422	1295	2717	1378	1241	2619